Monday
   January 5, 2009

Health Alerts
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| Hand Washing 101 | Why a Yearly Flu Shot Can Protect Your Heart | A Medication Reminder |
| Health After 50 | Clostridium difficile, A Dangerous Superbug | Diet and Longevity |
| Heart Failure | Should You Have Surgery For Sciatica? | How Low Should You Go? |
| Red Flag For Women | It Could Be A Warning of A Stroke | Detecting Delirium |
| Gastroesophageal Reflux Disease (GERD) | Distinguishing Normal "Senior Moments" | Sleep and your Blood Pressure |
| Nonprescription Decongestant-type Nasal Sprays | Primer on Cataracts | Antidepressant-Induced Sexual Dysfunction |
| Viagra and Sleep Apnea |
Potentially Inappropriate Drugs for Older Adults
As the years add up, it's not unusual for the number of daily medications we take to increase.Older persons may have trouble tolerating medications better suited for younger patients.

One of the most important steps you can take to protect yourself is to supply all of your doctors, particularly specialists, with as complete a medical status as possible, including a list of conditions you have and the drugs and supplements you take.

The following 33 drugs are considered to be potentially inappropriate for patients 65 years of age and older and may result in various adverse effects:

DRUG(generic/brand name) ADVERSE EFFECTS

  • Barbiturates(Nembutol, Mebarol, Amobarbital, Butabarbital, Pentabarbital, Secobarbital) Highly addictive,more adverse effects than most sedatives
  • Flurazepam(Dalmane, Somnol, Novo-Flupam, Apo-Flurazepam)May cause Central Nervous System (CNS) problems
  • Meprobamate(Equanil, Meprospan 200, Meprospan 400, Probate, Apo-Meprobamate Highly addictive
  • Chlorpropamide(Diabinese, NovoPropamide, Apo-Chlorpropamide)Prolonged hypoglycemia-Low blood sugar
  • Meperidine(Demerol) Confusion,CNS problems
  • Pentazocine(Talwin, Talwin Nx)Confusion,Hallucinations
  • Trimethobenzamide(Tigan,Stemetic,Tebamide, Tribenzagan, Trimazide)Can effect motor control
  • Belladonna alkaloids(Donnatal,Barbidonna)Hallucinations,confusion
  • Dicylomine(Bentyl, Bentylol, Spasmoban, Formulex) Nausea,Hallucinations
  • Hyoscyamine(Levsin,Hyosol, A-Spas-S/L, Cystospaz, Levbid, Levsinex Timecaps, Symax SL) Arrhythmia,dizziness,blurred vision
  • Propantheline(Pro-Banthine)Arrhythmia,dizziness,blurred vision
  • Carisoprodol(Soma,Vanadom)Poorly tolerated,weakness
  • Chlorzoxazone(Parafon Forte DSC, Remular-S, Paraflex) Poorly tolerated,weakness
  • Cyclobenzaprine(Flexeril)Poorly tolerated,weakness
  • Metaxalone(Skelaxin)Poorly tolerated,weakness,sedation
  • Methocarbamol(Robaxin)Poorly tolerated,weakness,sedation
  • Amitriptyline(Elavil)Poorly tolerated,sedative effects unpleasant
  • Chlordiazepoxide(Librium)Strong sedation,Adverse CNS effects
  • Diazepam(Valium)Prolonged sedation,risk of falls
  • Doxepin(Sinequan)Poorly tolerated,sedative effects unpleasant
  • Indomethacin(Indocin)Adverse CNS effects
  • Dipyridamole(Persatine)Sudden blood pressure drop
  • Ticlopidine(Ticlid)Anti-clotting,more toxic than aspirin
  • Methyldopa(Aldomet,Aldoril)Low resting heart rate,exacerbate depression
  • Reserpine(Harmonyl, Serpasil, Serpalan, Novoreserpine) Depression,sedation, blood pressure drop
  • Dispyramide(Norpace, Norpace CR)Could induce heart failure,other complications
  • Oxybutynin(Ditropan,Ditropan XL,Oxytrol)Weakness, sedation, poor tolerance
  • Chlorpheniramine(Chlor-Trimeton,Aller-Chlor, Chlorate, Chlo-Amine)Increased heart rate,disorientation
  • Cyproheptadine(Periactin)Increased heart rate, disorientation
  • Diphenhydramine(Benadryl,Nytol)Increased heart rate, disorientation
  • Hydroxyzine(Vistaril,Rezine, Atarax)Increased heart rate, disorientation
  • Promethazine(Pheneragan, Promacot)Increased heart rate, disorientation
  • Propoxyphene(Darvon, Darvon-N)Highly addictive;avoid if depressed with suicidal thoughts.
UCLA Medical Center, Division of Geriatrics and Johns Hopkins Medical Letter, Health After 50
September 2008

Hand Washing 101
One of the things that you didn't learn in kindergarten and, in all probability, didn't learn from your Mom either is how to effectively wash your hands! That may sound silly to you but, in truth, the best defense against bacteria, even the dreaded superbugs like Methicillin-resistant Staphylococcus (MRSA) and Clostridium difficile (C.diff), is to keep your hands scrupulously clean. This is how you should do it:

Use warm water, not hot water and not cold water because hot water is hard on the hands and cold water will inhibit the sudsing of soap.

Next, you do not have to use expensive antibacterial soaps to try to kill the germs but you do need to work up a substantial lather of soap suds to dislodge the bacteria and suspend them in the suds.

While lathering your hands be sure to soap every millimeter of skin, including the thumbs, between the fingers, the backs of the hands and the undersides of the fingernails. Use a nail brush to be even more effective.

Now rinse your hands thoroughly with warm water to remove every last trace of soap suds (and germs).

Now that you have done such a great job, do not negate you efforts by grabbing the faucet tap (loaded with germs) or a door knob (especially in a public restroom). Instead use a paper towel to shut off the water and to open the door. That will go a long way in preserving the clealiness of your hands.

Last of all - teach a child how to wash his or her hands!



Why a Yearly Flu Shot Can Protect Your Heart
The newest tool for preventing heart attack is a flu shot!Between 10% to 20% of people catch the flu annually, and a bad case can be deadly for individuals with coronary heart disease. Yet only one in three adults with cardiovascular disease gets an annual flu shot.

People with heart disease are not only at higher risk for flu than the general population but also are more likely to have a severe case and to develop complications such as viral or bacterial pneumonia. What's more, the flu can worsen coronary heart disease and trigger a heart attack.

No one is absolutely sure how the flu increases the risk of a heart attack. One possibility is that the inflamation associated with the flu can trigger the rupture of unstable plaque, leading to the formation of a blood clot that could cause a heart attack.

The strongest evidence for protection from a flu shot in people with heart disease comes from the Flu Vaccination in Acute Coronary Syndromes (FLUVACS) study. In that study, some 300 individuals who had been hospitalized for either a heart attack or a planned angioplasty were randomly assigned to receive a flu vaccine or remain unvaccinated. Over the next year, twice as many of the unvaccinated group (23%) died of heart disease, had a nonfatal heart attack, or developed severe ischemia (insufficient blood supply to the heart tissue), compared with those who were vaccinated (11%).

The American Heart Association (AHA) recommends a flu shot with the same enthusiasm as it does the control of cholesterol, blood pressure, and other modifiable risk factors for heart atacks. In a scientific advisory issued by the AHA and the American College of Cardiology heart doctors were asked to do something they may not normally do - give their patients flu shots. The Centers for Disease Control and Prevention has issued extensive recommendations pertaining to those individuals who should obtain flu shots. Go to our Home Page and click on Flu Alert for full details.

Besides getting a flu shot, two other simple measures - frequent hand washing (see Hand Washing 101) and, if possible, avoiding close contact with a flu sufferer - can help reduce the risk of catching the flu.

Johns Hokins Health Alerts

A Medication Reminder
Taking medication as prescribed is an essential part of caring for yourself while you are ill, but a recent study from Emory University found that 20-50% of patients take their medications incorrectly. Reminders, like pill boxes labeled with days of the week can help people keep track of their medications. And now the federal Agency for Healthcare Research and Quality (AHRQ) has created a pill card to give you another way to remember what you need to take and how to take it.

You can find the AHRQ card template on the Internet at ( www.ahrq.gov/qual/pillcard/pillcard.htm) and print it out or save it to your personal computer so you can customize it with your own medication instructions.

To avoid medication mix-ups, the AHRQ recommends that you describe each type of pill - its shape and color, for instance - and note any distinct markings if two pills look alike. To help with this, the AHRQ website contains images of pills that you can copy, color on the computer, and add to your pill card. You can also do this by hand.

Keep your pill card near your medications or in a visible place, like on the refrigerator or bathroom mirror.

Review your pill card with your doctor periodically to make sure that your dosages are correct and that you're not still taking anything that you do not need. Also, check with your pharmacist if you notice a change in the color, shape or size of your pills - generic medicines in particular often change appearance.

The Johns Hopkins Medical Letter

Health After 50
This article will include various Longevity Facts that have been condensed from their respective sources.

Depression coupled with hostility can be a dangerous combination. Researchers measured inflammatory proteins associated with cardiovascular disease in 316 people ages 50-70 and found that blood levels were higher in participants who showed signs of both hostility and depression. Psychosomatic Medicine, vol.70, p197.

Researchers from Finland and Canada examined 33 sets of male twins who reported divergent risk factors for back pain (e.g., one brother had a sedentary job while the other's work required heavy lifting). Despite differences in risk, many brothers both had back pain. Shared back pain was greatest between identical twins - whose DNA is the same- suggesting back pain may be due in part to genetic factors. Pain, vol.131, p272.

A recent study links strong social ties to a healthier recovery after injury. Among 674 hip fracture patients, those who'd seen or phoned a friend once a day during the two weeks before their injury were less likely to die within the next two years than patients without such frequent personal contact. Journal of the American Geratric Society, vol.56, p.1069.

Combined data from 7 studies that followed participants for up to 36 years found that obesity and being underweight (a body mass index of 18.5 or less) were associated with an increased risk of dementia. Other illnesses, like hypertension, type 2 diabetes, and cardiovascular disease, may have contributed to the elevated risk. Obesity Reviews, vol.9, p204.

Men who exercise regularily appear more likely to survive cancer and less likely to get it. According to a European study of over 40,000 men ages 45-79, cancer was 16% less common among men who exercised 60-90 minutes each day than in sedentary men. And among men who developed cancer, those who reported exercising moderately - such as walking or biking for 30 minutes per day - were 33% more likely to be alive at the end of the 7 year study than cancer patients who did not excercise. British Journal of Cancer, vol. 98, p. 1865

Psyllium fiber supplements like Metamucil do not appear to reduce inflammatory markers associated with cardiovascular risk (such as C-reactive protein) in overweight and obese adults who do not have heart disease. These findings, from a 3 month study of 158 obese and overweight participants ages 40-65, do not disprove previously reported anti-inflammatory benefits that may be derived from fiber in food.Annals of Family Medicine, vol. 6, p. 100.

Johns Hopkins Medical Letter
2008

Clostridium difficile, A Dangerous Superbug
There are probably very few of us who haven't been hospitalized at one time or another. Illnesses that you acquire during a stay in a hospital or longterm care facility are by no means new; however, in recent years, the infections have reached epidemic proportions in these institutions world wide. One of the most widespread and potentially serious of these illnesses is caused by the bacterium Clostridium difficile. This superbug is also known as Clostridium difficile Colitis, C.diff, C.difficile, Antibiotic Associated Colitis,CD, AACD and CDC.

C.difficile bacteria are everywhere in the environment. Three percent of healthy humans carrry it in the gut, but carriage rates in hospital patients tend to be much higher, and elderly persons being treated with antibiotics are most at risk of developing infections.These bacteria produce spores when they encounter unfavorable conditions.Transmission of infection is through the ingestion of these spores which can survive on surfaces, floors and even clothing for years and, with the exception of chlorine bleach, are resistant to many disifectants and antiseptics, including alcohol hand gel. Do not conclude that C.difficile is confined exclusively to hospitals and similar institutions. It's also a growing problem among otherwise healthy people and the problem is growing worse. It is, according to the Centers for Disease Control, responsible for tens of thousands of cases of diarrhea and at least 5000 deaths.

Some people who are infected with C.difficile never become sick, though they can still spread the infection. Others have bouts of watery diarrhea with nausea and abdominal pain and cramping. And an increasing number of persons develop severe inflammations of the colon. Complications of C.difficile infections include dehydration, kidney failure, bowel perforation, toxic megacolon and death. Signs and symptoms of this potentially life threatening illness include profuse, watery diarrhea 10 or more times a day, a fever, often greater than 101F, abdominal pain which may be severe, blood or pus in the stool, nausea, dehydration and weight loss.

Although more people with no known risk factors, including children, are contracting C.difficile infections, your risk is greatest if you:

    Are taking or recently have taken antibiotics, especially ampicillin, amoxicillin,clindamycin, fluoroquinolones and cephalosporins. Other antimicrobials, including antiviral and antifungal drugs, and chemotherapy medications also can lead to increased risk.

    Are 65 years of age or older. Older adults have a disproportionately high infection rate.

    Have a serious underlying illness or weakened immune system.

    Are or have recently been hospitalized, especially for an extended period. In general, larger hospitals have higher infection rates than do smaller hospitals.

    Live in a nursing home or longterm care facility. Often the infection spreads when patients are transferred from hospitals to other facilities.

    Have had abdominal surgery.

    Have a chronic colon disease such as inflammatory bowel disease or colorectal cancer.

    Take prescription or over-the-counter antacids. By reducing stomach acid, these drugs may allow C.difficile to pass more easily into the intestine.

    Have had a previous C.difficile infection.

Among the steps you can take to stop C.difficile from infecting you is to take antibiotics only when absolutely necessary and, even then, ask your Doctor to prescribe one that has a narrow range that you take for the shortest period of time so as to disrupt intestional bacteria the least. You my also consider Probiotic Supplements which help replace beneficial bacteria that antibiotics destroy. Only Saccharomyces boulardi has proved effective in C.difficile infections however. Last of all, the simplest and one of the best preventatives is to wash, wash, wash your hands! See Hand Washing 101 article on this same Health Alerts Page.

Society for General Microbiology and Mayo Clinic

Diet and Longevity
One of the topics most thought about, most discussed, and the least acted upon with any degree of diligence is diet! Here is diet advice from five leading scientific journals that can help you mainain your health, prevent disease, and enjoy a healthy lifestyle.

  • Diet tip 1:"Cutting carbs" may help you trim your waistline and maintain your vision. Researchers at Tufts University analyzed the dietary habits of 4,099 people with age-related macular degeneration and found that participants who ate a diet with the most refined carbohydrates, such as cookies, candy, pasta, white bread, and crackers, were 17% more likely to go blind that those who consumed a diet with the least refined carbohydrates. Try eating complex carbohydrates like brown rice and wheat bread. From the American Journal of Clinical Nutrition, vo.. 86, p.1210

  • Diet tip 2: Some research suggests that the antioxidant lycopene, which is found in abundance in tomatoes, may help prevent certain cancers. But after reviewing more than 140 related studies, the FDA gave its lowest "strength of evidence" rating to this claim. Do not give up on tomatoes, though! They are an excellent source of vitamins C and A, and eating a diet rich in antioxidants has other health benefits. From the Journal of the National Cancer Institute, vol. 99, p. 1074

  • Diet tip 3: The key to weight loss may be old-fashioned caloric cutting and exercise - plus realistic expectations. A review of 80 studies found that weight-loss programs that focused on only exercise were ineffective after six months, whereas people who dieted and didn't exercise lost 5-9% of their starting weight within six months. Keeping the pounds off was another story. After four years, a modest 3-6% reduction was sustained - and only through consistent dieting and exercise. From the Journal of the American Dietetic Association, vol. 107, p. 1755.

  • Diet tip 4: According to the Physicians Health Study, which recorded the dietary habits of over 21,000 male physicians for almost 20 years, men who ate whole-grain cereal every day were 28% less likely to develop heart failure over the course of the study than men who did not eat whole-grain cereal. The authors recommend that people look for "100% whole-grain" cereal that has at least 4 grams of whole grain per serving. From the Archives of Internal Medicine, vol. 167, p.2080

  • Diet tip 5: Excess uric acid, which causes gout and may play a role in chronic conditions like high blood pressure, may be linked to sugar consumption - but only in men! A dietary study of 4,073 men and women over 18 years of age found that men who consumed the most sugary drinks had high levels of uric acid; notably, sugar did not boost levels in women, possibly because estrogen is protective. If you've got a sweet tooth, try fruit juice; it doesn't increase uric acid. From the journal Hypertension, vol. 50, p. 306

  • Diet tip 6:If you eat fast, you get fat! So if you want to lose weight, slow down at mealtime and do not stuff yourself. People who wolf down their food are three times more likely to be overweight than those who eat at a leisurely pace or stop eating before they feel full. The findings come from a three-year survey of 3000 men and women, ages 30 to 69, in Japan. Researchers at Osaka University found that women are more likely than men (58 to 51 percent) to chow down until they feel full, while more men than women (46 to 36 percent) say they are speedy eaters. From the October 18th British Medical Journal.
  • Johns Hopkins Health Alerts

    Heart Failure
    The words "heart failure" certainly sound scary. If you've been told that you have heart failure or you're at risk, you may fear that your heart is about to quit working at any second! What heart failure really means is that your heart isn't working as well as it should. Your heart muscle has weakened, and it can't pump enough oxygen-rich blood to meet all of your body's needs. With proper treatment, many people with heart failure experience an improvement of symptoms and heart function and live relatively normal lives.

    If you've been diagnosed with heart failure or have been told that you may be at risk, it's important that you work with your doctor to develop a treatment plan that addresses your needs and the severity of your disease. The two basic components of most treatment plans are medication and lifestyle changes.

    The best way to respond to heart failure is to educate yourself, listen to your doctor's advice and pay attention to what your body is telling you.

    Warning signs of heart failure tend to develop gradually. Because they come on slowly, in the disease's early stages, signs and symptoms may be missed or attributed to another condition. Here are some of the most common signs and symptoms of heart failure and some of what causes them.

    Shortness of Breath- Because the heart can't pump blood fast enough, it "backs up" in the veins that connect the lungs to the heart causing fluid to leak into the lungs, producing shortness of breath, especially when lying down.

    Cough or Wheezing-Similar to shortness of breath, the leaking fluid into the lungs produces a cough or wheeze.

    Swelling of Body Tissues-When blood flow back to the heart slows, fluid builds up in tissues such as the lungs, feet, legs and abdomen. The kidneys also become less efficient in disposing of water and sodium. making tissues more susceptible to fluid retention.

    Weight Gain- Fluid retention causes weight gain

    Fatigue-With a reduced supply of freshly oxygenated blood to meet the body's needs, blood is diverted away from less vital organs, particularly muscles in the arms and legs, making them more susceptible to fatigue.

    Reduced Appetite and Nausea-The digestive system receives less blood, thereby reducing appetite and causing digestive problems.

    Difficulty Concentrating-Changes in blood components, such as an increase in sodium, can affect alertness, as can not getting enough blood to the brain.

    Increased Heart Rate-To try to make up for its reduced capacity to pump blood, the heart beats faster.

    Mayo Clinic Health Letter Special Report

    Should You Have Surgery For Sciatica?
    If you have sciatica and find that rest and pain medication are not working to relieve your pain, should you consider surgery? Recent research provides the answer.

    Sciatica refers to leg pain caused by a herniated disk in the spine that presses on the sciatic nerve. People with sciatica often experience intense pain that radiates into the buttocks, down the thighs, and into the calves, and often into the feet.

    Surgery can provide fast pain relief for sciatica, but you might do just as well without an operation, a study finds.

    In this study, researchers randomly assigned 281 people with sciatica for at least six weeks to have surgery to decompress the nerve; or, to receive conservative treatments such as pain medication and exercise. On average, people who had sciatica surgery felt their leg pain was better after four weeks while it took about 12 weeks for those who did not have surgery to note improvement. But within one year, 95% of the study participants said they felt significntly better, no matter which sciatica treatment they had.

    Bottom line advice: If you are experiencing searing pain or numbness in your leg from sciatica and conservative treatment is not working, then surgery may be right for you. On the other hand, if you feel you can handle the leg pain and are willing to postpone sciatica surgery, you might find that you don't need it. Always discuss options with your doctor.

    The New England Journal of MedicineVolume 356, page 2245
    2008

    How Low Should You Go?
    Aggressively treating high blood pressure may not be good medicine after age 80, according to a new study reported in the Journal of the American Geriatrics Society(Volume 55, page 383)

    In this study, researchers looked at the medical records of more that 4,000 veterans age 80 and older with high blood pressure. Participants who lowered their blood pressure to just below the upper limit of normal - 139/89 mm Hg - were less likely to die of any cause over a five year period than those who reduced their blood pressure to lower levels. This relationship held when the researchers took into account other illnesses that can lead to premature death.

    These findings do not contradict current guidelines that recommend lowering blood pressure to below 140/90 mm Hg. But they do suggest that aggressive lowering of blood presure beyond this level could be harmful for people over age 80, possibly because of reduced blood flow to vital organs.

    If you are 80 or older and experience any symptoms of aggressive blood-pressure lowering such as dizziness, weakness, or thinking problems tell your doctor who then may make changes to your treatment regimen.

    Johns Hopkins Health Alerts, Hypertension and Stroke
    August 2008

    Red Flag For Women
    Contrary to typical portrayals in movies and on TV, heart attacks don't always have a sudden, intense onset. A recent study finds that for women, chronic chest pain may signal a future heart problem.

    Although no one likes to think about having a heart attack,would you know what to do if you were? Even if you know what to do, would you follow through and more importantly, would you do it quickly?

    According to the National Heart, Lung, and Blood Institute close to one million people in the United States have heart attacks each year; and, about one fifth of them die. Half of the deaths occur in the first hour after heart attack symptoms start and before the person reaches a hospital. These numbers underscore the importance of recognizing heart attack symptoms quickly and responding to these symptoms just as quickly,

    Now a study in the European Heart Journal (Volume 27, page 1408) reports that for women, persistent chest pain may be a waning of future heart problems - even when a woman has no evidence of blockages in her coronary arteries.

    The findings come from a study known as WISE, a government-funded project designed to evaluate chest pain in women - a task that is less straightforward than in men. The central isue is that women are much more likely than men to suffer long-term chest pain in the absence of any large artery blockages. But that doesn't mean their chest pain is innocuous.

    Among women in the study with no signs of clogged arteries, those with persistent chest pain for at least a year were more that twice as likely to suffer a heart attack, stroke or other cardiovascular complication over the next five years. The study included 637 women whose chest pain and other potential symptoms of coronary heart disease were evaluated by angiography (an x-ray examination of blood vessls that can detect blockages).

    The take home message is if you are a woman, you should not simply live with chronic chest pain if angiography fails to detect artery blockages. Instead, you should ask your doctor about ways you can reduce any heart risk factors you have. Remember, a healthy diet and regular physical activity are two of the most important ways.

    Johns Hopkins Health Alerts

    It Could Be A Warning of A Stroke
    Recent research from the Journal Neurology explains why acting promptly at the first sign of a transient ischemic attack (TIA) may prevent a major stroke.

    You probably know the symptoms of a heart attack, but it's just as important to know the symptoms of a stroke. Like a heart attack, a stroke is an emergency that requires immediate medical attention. Even a TIA, in which the stroke symptoms appear suddenly and quickly subside, is a medical emergency.

    Whether you are having an ischemic or hemorrhagic stroke, the symptoms are the same. With a TIA,the symptoms are transitory, often lasting only minutes. If you or someone you are with experiences the sudden onset of any of the stroke symptoms listed below - even if the symptoms start to subside - you MUST call 911 or go straight to the hospital. Rapid diagnosis and treatment of a stroke may minimize damage to the brain tissue and improve the chances of survival. Stroke symptoms include:

    Sudden weakness or numbness in the face, arm, or leg on one side of the body.
    Sudden loss, blurring,or dimness of vision.
    Mental confusion, loss of memory, or sudden loss of consciousness.
    Slurred speech, loss of speech, or problems understanding others.
    A sudden, severe headache with no apparent cause.
    Unexplained dizziness, drowsiness, or lack of coordination.
    Nausea and vomiting, especially when accompanied by any of the preceding symptoms.

    The importance of responding immediately to symptoms of a stroke is underscored by a study in the journal Neurology(Volume 64, page 817). Note that the warning signs of an ischemic stroke may occur up to seven days before the event itself, according to researchers, and these signs should be taken seriously to minimize the chance of a major stroke.

    Johns Hopkins Medicine

    Detecting Delirium
    Delerium may be difficult to detect, particularly in people with memory problems or dementia. Be sure to make allowances for certain personality traits - tell the doctor if a loved one is typically restless or introverted, for instance.

    There is no universal rating system to help determine if a patient has delerium; however, the reliability of the following criteria tested positively in a study published in the Journal of Geriatric Psychology. Some central characteristics that researchers identified are listed below. Examples of the type of behavior that might indicate each characteristic are also included.

    Shifting attention
    Unable to concentrate during conversations.
    Switches topics frequently.
    Easily distracted.
    Completely inattentive.

    Poor orientation
    Has problems articulating the date.
    Doesn't know the days of the week.
    Doesn't know where he or she is.
    Has trouble recognizing family members.

    Incoherence
    Speech is difficult to understand.
    Stops in the middle of a sentence.
    Cannot express thoughts.

    Restlessness and anxiety
    Jumpy, edgy, or fidgety.
    Suspicious of others.
    Anxious and afraid.
    Requires frequent reassurance.

    Delusions and hallucinations
    Perception is distorted or completely wrong.
    Sees shapes or objects incorrectly.
    Smells scents that are not there.

    Poor cognition
    Cannot spell simple words backwards.
    Cannot do simple math.
    Cannot recognize simple patterns of words or numbers.

    Johns Hopkins Medical Letter

    Gastroesophageal Reflux Disease (GERD)
    Many people, including some 79% of those with gastroesophageal reflux disease suffer heartburn that awakens them during the night. While this is by far the most common symptom of GERD, there are about 10-15% of people with gastroesophageal disease who do NOT have heartburn! Instead, they experience asthma, a chronic cough, chest pain, or laryngitis. These symptoms result when stomach acid refluxes into organs connected to the esophagus, such as the larynx, trachea and lungs.

    Research reported in the journal Chest (Volume 127, page 1658 May 2005) shows that people who are overweight, drink a lot of carbonated beverages, snore, experience daytime sleepiness or insomnia, have a high blood pressure or asthma, or use anti-anxiety medications such as diazepam (Valium) are most likely to experience the problem.

    The subjects were part of the Sleep Heart Health Study, a national trial that enrolled 15,314 people to investigate the link between breathing problems during sleep and cardiovascular disease. Among the questions was "how often in the past year, on average, have you been awakened during the night with heartburn or indigestion?" The responses indicated that 1/4 or 3,806 people, in this group reported the symptom at least twice a month. People with nighttime heartburn are at greater risk for more serious esophageal problems such as erosive esophagitis, Barrett's esophagus, and esophageal cancer.

    If you experience nighttime heartburn on a regular basis, or have bouts of asthma, a nagging cough or episodes of chest pain, talk with your doctor. In addition, try to control the risk factors identified in this study - for example, keep your weight and blood pressure under control and cut down on your soda intake.

    Johns Hopkins Medicine and Johns Hopkins Health Alerts

    Distinguishing Normal "Senior Moments"
    Concerned about memory? Johns Hopkins doctors compare symptoms of normal aging with those of more serious dementia.

    Occasional memory lapses, such as forgetting why you walked into a room or having difficulty recalling a person's name, become more common as we approach our 50s and 60s. It's comforting to know that this minor forgetfulness is a normal sign of aging, not a sign of dementia.

    Here are examples of the types of memory problems common in normal age-related forgetfulness, mild cognitive impairment and dementia.

    Normal Age-Related Forgetfulness:

    Sometimes misplaces keys, eyeglasses, or other items.
    Momentarily forgets an acquaintances's name.
    Occasionally has to "search" for a word.
    Occasionally forgets to run an errand.
    May forget an event from the distant past.
    When driving, may momentarily forget where to turn. Quickly orients self.
    Jokes about memory loss.

    Mild Cognitive Impairment:

    Frequently misplaces items.
    Frequently forgets people's names and is slow to recall.
    Finding the desired word becomes more difficult.
    Begins to forget important events and appointments.
    May forget more recent events or newly learned information.
    May temporarily become lost more often.
    May have trouble understanding and following a map.
    Worries about memory loss. Family and friends notice the lapses.

    Dementia:

    Forgets what an item is used for or puts it in an inappropriate place.
    May not remember having known a person.
    Begins to lose language skills. May withdraw from social interaction.
    Loses sense of time. Doesn't know what day it is.
    Short-term memory is seriously impaired. Has difficulty learning and remembering new information.
    May have little or no awareness of cognitive problems.

    Johns Hopkins Health Alerts

    Sleep and your Blood Pressure
    Another reason to catch your Z's has to do with healthier blood pressure. In 90-95% of people with high blood pressure, doctors are unable to pinpoint the exact cause. In these cases, the condition is called essential or primary hypertension, In the remaining 5-10% of people, doctors are able to identifly a cause, and this type of high blood pressure is called secondary hypertension.

    Now researchers may have found a connection between sleep habits and high blood pressure. In a study reported in the Journal Hypertension(Volume 47, page 833) researchers studied more than 4,800 Americans and found that young and middle-aged adults who clocked five or fewer hours of sleep each night were 60% more likely than their well-rested peers to develop hypertension over the next decade. Lack of sleep did not appear to raise blood pressure in adults older than age 59, however.

    The link between sleep habits and blood pressure remained even agter the researchers controlled for weght, depression, smoking, and physical activity levels. This means there may be something about chronic sleep deprivation that raises a person's blood pressure.

    One possibility us that people who get little sleep have more exposure to the elevations in heart rate, blood pressure, and nervous system activity that come with being awake. As a result, the body may adapt to these chronic elevations by operating at anew, higher level. Chronic sleep deprivation might also throw a wrench in the central "clock" in your brain, which governs the rythem of bodily processes, including blood pressure control. People vary in the amount of sleep they need, but experts recommend that adults get at least a good six hours of sleep a night.

    John Hopkins Health Alerts

    Nonprescription Decongestant-type Nasal Sprays
    Often people want to know whether nonprescription nasal sprays are addictive. Technically, the answer is no they're not addictive; however, they can cause problems that lead to a vicious cycle of using one on a daily basis. In general, they're best reserved for short-term use of no more than two or three days.

    Here's why:
    Nasal congestion occurs when the blood vessles in the lining of your nose expand due to a cold or allergies. nonprescription decongestaant nasal sprays such as phenylephrine (Vicks Sinex, others) and oxymetazoline (Afrin, others) reduce that congestion by narrowing those blood vessles.

    The problem is that after a few days of relief, your nasal membranes become tolerant and less responsive to the spray. The typical response is to use more spray more frequently. Not using the spray can result in rebound congestion - a period of brief relief followed by severe nasal obstruction.

    To reverse tolerance to these sprays stop using them for several weeks. Instead, try using saline nasal sprays which don't cause rebound congestion. If your congestion is related to allergies, try a nonprescription antihistimine decongestant tablet or ask your doctor about prescription nasal sprays, such as azelastine (Astelin), budesonide (Rhinocort Aqua), fluticasone (Flonase),ipratropium bromide (Atrovent), mometasone (Nasonex) and triamcinolone acetonide (Nasacort AQ). These sprays are generally safe for extended use and do not cause rebound congestion.

    Mayo Clinic Health Letter

    Primer on Cataracts
    If you're in your forties or fifties, you probably know someone who has cataracts. That's because cataracts can occur at any age (in fact, babies can be born with them), they are most common later in life. About 50% of people age 65-74 and 70% of those age 75 and older have cataracts. In 2004, an estimated 20.5 million Americans over age 40 (approximately 17%) had a cataract. Cataract surgery is the most commonly performed surgical procedure in the United States. More than 1.5 million cataract operations are performed each year.

    The cause of most cataracts is unknown, but at least two factors associated with aging contribute to their development. First, clumping of proteins in the lens leads to scattering of light and a decrease in the transparency of the lens. Second, the breakdown of lens proteins leads to the accumulation of a yellow-brown pigment that clouds the lens.

    Researchers have found certain chemical changes in the eyes of people with cataracts. These changes include a reduced uptake of oxygen by the lens and a rise in the water content of the lens, which is later followed by dehydration. When cataracts form, levels of calcium and sodium in the lens increase, and levels of potassium, vitamin C, and protein decrease. In addition, lenses with cataracts appear to be deficient in the antioxidant glutathione; however, studies on the use of medications or vitamins to alter the levels of these substances in the lens have not produced promising results. Currently, there is no effective drug therapy to prevent cataracts from forming. But cigarette smoking, certain drugs, eye injuries, sunlight, diabetes and even obesity can increase the risk of cataracts.

    Cataracts are an opacification (cloudiness) of the eye's normally clear crystalline lens and they form painlessly. The most common symptom is cloudy or blurry vision and everything becomes dimmer, as if seen through glasses that need cleaning. Most often, both eyes are affected, though vision is usually worse in one eye than in the other. Other symptoms include glare, halos, poor night vision, a perception that colors are faded or that objects are yellowish, and the need for brighter light when reading. Symptoms can develop rapidly (in a matter of months) or almost imperceptibly over many years.

    Johns Hopkins Medicine

    Antidepressant-Induced Sexual Dysfunction
    Karen L. Schwartz, M.D., Director of Clinical Programs at the Johns Hopkins Mood Disorders Center weighs in on this all too common cause of decreased libido. Unfortunately, sexual dysfunction includes diminished libido, inability to orgasm, decreased sensation in the genitals, vaginal dryness, and erectile dysfunction.

    If you report sexual dysfunction, the first thing your doctor will do is a thorough medical workup to rule out such physical problems as hypertension, diabetes, urological problems and neurological problems, all of which can cause such dysfunction.

    If antidepressants are the likely cause, there are several possible remedies. First, you and your doctor may consider switching to an antidepressant with a low rate of sexual side effects, such as Wellbutrin (bupropion). This would be done carefully to minimize the risk of a relapse of depression. Your doctor may also suggest adding Wellbutrin to your current antidepressant regimen. Research has shown that small doses of Wellbutrin in combination with other antidepressants can be helpful in alleviating the sexual side effects of those antidepressants. There are a number of other remedies that you and your doctor might try such as adding sildenafil which is effective for combating antidepressant-induced sexual dysfunction in both men and women. Perhaps your doctor may decrease your antidepressant dose to some slight degree or change the time you take your medication. Dividing the medication dose and taking it twice a day may also diminish side effects. Finally, your doctor may have you take a "drug holiday" for a two day period which will lower the rate of sexual side effects without increasing the risk of a recurrence of depressive symptoms.

    All remedies discussed above should be implemented only with physician support and supervision to prevent relapse of depressive symptoms and drug withdrawl reactions.

    Depression and Anxiety

    Viagra and Sleep Apnea
    Sleep apnea is a disorder characterized by repeated episodes of breathing cessation (apnea) during sleep. These episodes last from 10 seconds to nearly a minute, ending with a brief partial arousal. Episodes of sleep apnea can occur and disrupt sleep hundreds of times throughout the night. An estimated 18 million Americans hve obstructive sleep apne, yet 95% of them are undiagnosed and untreated. Sleep apnea is about twice as common among men as among women.

    A report in the Archives of Internal Medicine(9Volume 166, page 1763) suggests that taking Viagra at bedtime may worsen severe obstructive sleep apnea. This may be disturbing news to many men, because erectile dysfunction is particularily common among those with sleep apnea. Viagra prolongs the action of nitric oxide, which promotes upper airway congestion, thereby contributing to sleep apnea. The researchers studied 14 men with severe sleep apnea, who spent a night in a sleep lab having their breath and blood oxygen monitored after they took a single 50-mg dose of Viagra or a placebo.

    Just one dose of Viagra significantly increased the amount of sleep time with a lower blood oxygen saturation level; while asleep, men who took Viagra were not getting as much oxygen as those wo took a placebo. They also had more breathing pauses per hour.

    Bottom line advice on Viagra and sleep apnea is if you take Viagra and have sleep apnea, talk with your doctor about whether the pleasures you derive from taking the drug outweigh the risks of worsening your nighttime breathing problems.

    Johns Hopkins Health Alerts

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